Studies of Complexation of Transition Metal Ions With Benazepril Drug in Aqueous Media: Thermodynamic Aspect


Shailendrasingh Thakur, M. A. Sakhare, D. B. Jirekar, Ramesh Ware, P. P. Ghumare

Stability constant of Benazepril hydrochloride drug with transition metal ions Fe3+, Co2+, Ni2+, Cu2+, Zn2+ and Cd2+ using a pH metric titration technique in 20%(v/v) ethanol-water mixture at three different temperatures 300K, 310K & 320K at an ionic strength of 0.1M NaClO4 were studied. The Calvin-Bjerrum method as adopted by Irving-Rossotti has been employed to determine metal-ligand stability, constant logK values. The trend in the formation constants for transition metal ions follows the order: Fe3+ > Cu2+ > Cd2+> Co2+ > Zn2+ > Ni2+The thermodynamic parameters, such as Gibb’s free energy change (ΔG), entropy change (ΔS), and enthalpy change (ΔH) associated with the complexation reactions, were calculated.


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