Abstract
Anatoliy Reder, Vitalii Larionov, Nikolay Golovenko, Sergey Andronati
The granulometric composition of new analgesic substance (7-bromo-5-(o-chlorophenyl)-3-propoxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one) was characterized by methods of crystals microscopy and lazer diffraction,. The single polymorphic phase demonstrated by differential scanning calorimetry, X-ray diffraction analysis, Raman and IR-spectroscopy. On the base of the anticonvulsive effect on mice in compare to coarse ?crystalline sample the conclusion about the higher pharmacological effect for the disperse sample had been demonstrated.
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